BindingDB BDBM378885 US10266537, Compound 93

BDBM378885 US10266537, Compound 93

SMILES Cc1ccc(NC(=O)c2ccc(C)c(c2)C(F)(F)F)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12

InChI Key InChIKey=YHVHYWYQEFELOW-HZCBDIJESA-N

Data 85 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 378885

RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
St. Chuan University

US Patent

BDBM378885(US10266537, Compound 93)

IC50: 52nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details US Patent

RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
St. Chuan University

US Patent

BDBM378885(US10266537, Compound 93)

IC50: 52nMAssay Description:Inhibition of human recombinant c-RAF Y340D/Y341D mutant (306 to end residues) using inactive MEK1 as substrate incubated for 40 mins in presence of ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

Details Article PubMed

Filter my 85 hits

Targets 55▿
- Tyrosine-protein kinase ABL1 3
- Serine/threonine-protein kinase B-raf 3
- Epidermal growth factor receptor 3
- Cytoplasmic tyrosine-protein kinase BMX 2
- Tyrosine-protein kinase Lck 2
- Discoidin domain-containing receptor 2 2
- Tyrosine-protein kinase ABL2 2
- Mitogen-activated protein kinase 11 2
- Mitogen-activated protein kinase kinase kinase 7 2
- Tyrosine-protein kinase Fyn 2
- Tyrosine-protein kinase CSK 2
- Protein-tyrosine kinase 2-beta 2
- RAF proto-oncogene serine/threonine-protein kinase 2
- Tyrosine-protein kinase Blk 2
- Tyrosine-protein kinase Lyn 2
- Receptor tyrosine-protein kinase erbB-2 2
- Tyrosine-protein kinase FRK 2
- Angiopoietin-1 receptor 2
- LIM domain kinase 1 2
- Protein-tyrosine kinase 6 2
- Tyrosine-protein kinase Yes 2
- Proto-oncogene tyrosine-protein kinase Src 2
- Vascular endothelial growth factor receptor 2 2
- Fibroblast growth factor receptor 1 2
- Tyrosine-protein kinase HCK 2
- Fibroblast growth factor receptor 2 2
- Vascular endothelial growth factor receptor 1 2
- Mitogen-activated protein kinase 1 1
- Ephrin type-A receptor 4 1
- Proto-oncogene tyrosine-protein kinase Src [1-530] 1
- Ephrin type-A receptor 7 1
- High affinity nerve growth factor receptor 1
- Tyrosine-protein kinase Mer 1
- Receptor tyrosine-protein kinase erbB-4 1
- Potassium voltage-gated channel subfamily H member 2 1
- Ribosomal protein S6 kinase alpha-3 1
- Ribosomal protein S6 kinase alpha-1 1
- Serine/threonine-protein phosphatase 1
- Hepatocyte growth factor receptor 1
- Mitogen-activated protein kinase 14 1
- Vascular endothelial growth factor receptor 3 1
- Fibroblast growth factor receptor 3 1
- Tyrosine-protein kinase receptor TYRO3 1
- Tyrosine-protein kinase ABL1 [T315I] 1
- Serine/threonine-protein kinase B-raf [V600E] 1
- Platelet-derived growth factor receptor alpha 1
- Ephrin type-B receptor 2 1
- Proto-oncogene tyrosine-protein kinase receptor Ret 1
- Activated CDC42 kinase 1 1
- Epidermal growth factor receptor [T790M] 1
- Epidermal growth factor receptor [T790M,L858R] 1
- Tyrosine-protein kinase TXK 1
- Platelet-derived growth factor receptor beta 1
- Epithelial discoidin domain-containing receptor 1 1
- BDNF/NT-3 growth factors receptor 1
Publications 2▿
- J Med Chem 59: 9788-9805 (2016) 48
- US Patent US10266537 (2019) 37
Institutions 2▿
- Sichuan University 48
- St. Chuan University 37
Affinity: 1 to 3.0E+4 nM▿
- IC50 85
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0